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Sulston score
The Sulston score is an equation used in DNA mapping to numerically assess the likelihood that a given "fingerprint" similarity between two DNA clones is merely a result of chance. Used as such, it is a test of statistical significance. That is, low values imply that similarity is ''significant'', suggesting that two DNA clones overlap one another and that the given similarity is not just a chance event. The name is an eponym that refers to John Sulston by virtue of his being the lead author of the paper that first proposed the equation's use.
== The overlap problem in mapping ==
Each clone in a DNA mapping project has a "fingerprint", ''i.e.'' a set of DNA fragment lengths inferred from (1) enzymatically digesting the clone, (2) separating these fragments on a gel, and (3) estimating their lengths based on gel location. For each pairwise clone comparison, one can establish how many lengths from each set match-up. Cases having at least 1 match indicate that the clones ''might'' overlap because matches ''may'' represent the same DNA. However, the underlying sequences for each match are not known. Consequently, two fragments whose lengths match may still represent different sequences. In other words, matches do not conclusively indicate overlaps. The problem is instead one of using matches to probabilistically classify overlap status.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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